Vascular endothelial cell growth factor may also contribute to tumour progression through its permeabilising effect on the vasculature (Dvorak et al, 1995; Roberts and Palade, 1997), and activation of VEGFR2 appears sufficient to promote the major phenotypic responses to VEGF, including endothelial cell proliferation, migration, survival and the induction of vascular permeability (Wedge et al, 2002). Here, KDR is linked to neoplasm.