For example, FLP binds to TTR, COX-1 and COX-2 with similar sets of interactions and inhibits both TTR amyloidosis (70% inhibition at 7.2 μM), COX-1 (IC50 = 0.41 μM) and COX-2 (IC50 = 4.2 μM) enzyme activity [22], [36]. This evidence concerns the gene TTR and amyloidosis.