From a phase II trial of bevacizumab plus irinotecan in patients with malignant astrocytoma, a comparative analysis was performed with several angiogenic factors including CA9 from tumor specimens by Sathornsumette et al. This phase II trial adopted a high dose regimen of bevacizumab, 10 mg/kg/2-wk [36]. The gene discussed is CA9; the disease is neoplasm.