To our surprise, cathepsin B treated HPV16 reporter-virions for 2 and 4 hours had a significant increase in infection levels (p < 0.05 1-tail t test) in the presence of furin inhibitor as compared to infection of untreated reporter-virions in the presence of furin inhibitor (compare Fig. 5A 2 and 4 hr bars to infected + Furin inhibitor bar). The gene discussed is CTSB; the disease is infection.