ERBB2 and neoplasm: Furthermore, co-culturing MCF-7 breast cancer cells overexpressing HER2 with endothelial cell monolayers displays that the increased metastatic potential of breast carcinoma may stem from HER2 induction of endothelial cell retraction, a process disrupting endothelial integrity and preceding endothelial cell transmigration in several tumor metastatic models [11], and the plausible mechanism involves both down-regulation of vascular endothelial cadherin and dissociation of catenins by HER2 [12].