AKT1 and breast carcinoma: Figure 7(c) displays that pterostilbene caused a dose-dependent decrease in HRG-β1-induced Akt phosphorylation, correlated well with anti-proliferating effect (Figure 5). Combined with these findings, we suggest that the blockage of HRG-β1-induced proliferation by pterostilbene via an inhibitory modification of Akt may partially contribute to anti-metastatic and invasive capacity of pterostilbene in MCF-7 breast carcinoma cells.