In block 1 that is composed of TNF-α-1031 T/C, TNF-α-863 C/A and TNF-α-857 C/T (D' = 1.0 and r2 = 0.037), compared to TCC-TCC without a variant allele, TCC-TCT showed a significantly increased risk for gastric cancer among total subject and smokers (OR = 2.1, 95% CI 1.1–3.9; OR = 2.6, 95% CI 1.2–5.8; respectively) but was not associated with gastric cancer risk among non-smokers (OR = 1.5, 95% CI 0.5–4.0). Here, TNF is linked to gastric cancer.