APOE and Alzheimer disease: Assessing the association between these previously described htSNPs in the CDK5 gene and late onset AD in a Dutch case-control series, Arias-Vásquez et al. [8] observed a 1.8-fold (p = 0.001) increased risk of AD for carriers of the GG genotype of SNP rs2069442 in the CDK5 gene in non-carriers of the APOE ε4 allele; in addition the CDK5 haplotype (GGGGG) composed of 5'UTR (rs2069442), intron 5 (rs2069454), intron 9 (rs891507 and rs2069459) and 3'UTR (rs9278) was significantly associated with AD (OR = 1.21, p = 0.05) in non-carriers of the APOE ε4 allele.