Moreover, TZDs, as other PPAR-γ agonists, such as the prostanoid 15d-PGJ2 [9], induce a variety of favorable changes (growth arrest, apoptosis, and/or partial redifferentiation) in several malignancies, including liposarcoma, and cancers of the breast, colon, pancreas, and prostate [10–18]. The gene discussed is PPARG; the disease is cancer.