In addition, other studies have revealed the poly-ubiquination and proteasomal degradation upon S82/112 phopshorylation of PPAR-γ as a mechanism of PPAR-γ inactivation in adipocytes [131, 132], breast [133] and colon cancer cells [134], after IFNγ, Her-2 and gastrin stimulation, respectively. Here, PPARG is linked to colonic neoplasm.