Both the baseline CSF levels of tau in the 1-year AD cohort (693±301 ng/l) and in the 2-year AD cohort (663±308 ng/l) were significantly elevated with 61–68%, when compared to the baseline levels in the control group (412±232 ng/l; P<0.001) (table 2). The gene discussed is MAPT; the disease is Alzheimer disease.