Given that PKD is a late-onset condition that progresses at a moderate rate in pc mutants, the medaka pc mutant has a relatively long life when compared with zebrafish pronephric models of cystic kidney, such as vHnf1, double bubble, and oval (polaris/IFT88/osm-5) mutants [16]–[23]. The gene discussed is PC; the disease is Renal cyst.