PSIP1 and HIV-1 infection: We hypothesized that fusion of one or more of these chromatin-binding domains to C-terminal regions of LEDGF/p75 that contain the IBD could result in chimeric proteins that would rescue HIV-1 IN tethering and HIV-1 infection in CD4+ human T cells that are LEDGF/p75-deficient and/or express interfering IBD fragments.