As a case in point, the top scoring pathway – Development_Role of HDAC and calcium/clamodulin-dependent kinase (CaMK) in control of skeletal myogenesis- (Figure 3) contains the calcium-gated channels CACNA1E and CACNA1H, IGF-1, and AKT, each of which is known to play a role in mechanisms of BP regulation, hypertension and/or complications of hypertension (including left ventricular hypertrophy) [16]–[21]. This evidence concerns the gene IGF1 and hypertensive disorder.