In this array survey, we sought to determine whether there exist additional candidate genes at 3q26-qter regions that drive genome differentiation of SCC from AC subtypes of NSCLC, and we were capable of detecting the following possible target genes previously not assumed to play a pathogenic role in SCC; LOC389174 (3q26.2),KCNMB3 (3q26.32),EPHB3 (3q27.1), MASP1 and SST (3q27.3), LPP and FGF12 (3q28), and OPA1,KIAA022, LOC220729, LOC440996,LOC440997, and LOC440998 (3q29), all of which were significantly targeted in SCC (P < 0.05). Here, EPHB3 is linked to non-small cell lung carcinoma.