MECOM and cancer: Several interesting cancer-related genes located in these genomic alteration regions have previously been identified with specific histologies, such as EVI1 (ecotropic viral integration site 1) and MDS1 (myelodysplastic syndrome 1) at 3q26.2,PIK3CA (phosphoinositide-3-kinase, catalytic, alpha polypeptide) at 3q26.32, and TP73L (tumor protein p73-like) at 3q28 region [40,41].