Four immune assays were chosen for study based on previous observations suggesting that they may correlate with protection against parasitaemia and/or clinical morbidity: malaria antigen specific T cell IFN-γ measured by ELISPOT [13,34-37], IgG antibodies to recombinant MSP-142 proteins measured by ELISA [5,6,8,10], MSP-119-specific IIA [20], and GIA [23,38]. The gene discussed is IFNG; the disease is malaria.