For example, MMPs including MMP-9, 2, 14, 3, 7, 12, 8 have been reported to be elevated at different stages of multiple sclerosis [4,13], and they are important promoters of immune cell extravasation into the CNS via the opening of the blood brain barrier due to their unique ability to facilitate fibronolysis [20]. The gene discussed is MMP9; the disease is multiple sclerosis.