MAP1LC3A and cancer: When we utilized this property of LC3 to initially monitor changes in the dynamics of the autophagic process in Tzb-sensitive and in Tzb-refractory cancer cells, both the total amount and, particularly, the lipidation status of LC3 (i.e. LC3-I is converted by lipidation to the phosphatidyl-ethanolamine conjugated form LC3-II) were drastically up-regulated in Tzb-unresponsive TzbR POOLs whereas LC3-I/LC3-II proteins were hardly detectable in Tzb-naive SKBR3 parental cells (Figure 2).