In vitro, IM/BOR and IM/PSI exhibit an enhanced inhibition of long-term colony forming activity and short-term cell growth of CD34+ cells from CML patients at CP or BC (Figure 3), cause potentiated proliferation inhibition in K562 and 32D cells expressing BCR-ABL (Figure 4 and 5), and exert significantly potentiated apoptotic effects on CML cells (Figure 6 and Figure S5). The gene discussed is BCR; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.