PLAT and Venous thrombosis: Another study using the same thrombosis model in dogs compared adjunctive infusion of ticagrelor (75 μg/kg IV bolus, followed by 10 μg/(kg·min) IV infusion over 2 h) with clopidogrel (10 mg/kg IV bolus over 5 min) and placebo, on top of fibrinolytic therapy (t-PA + heparin).