A potential role for these pathways in cancer was established when Wnt-5a was shown to signal through ROR2 to induce cellular migration and invasion in murine fibroblast NIH3T3 cells (Nomachi et al, 2008); if the same occurred in cancer cells, oncogenic potential could be conferred by Wnt-5a through the promotion of cancer cell invasion. This evidence concerns the gene ROR2 and cancer.