WNT5A and melanoma: In addition, Wnt-5a, in the presence of a CXCL12 chemokine gradient, was able to polarise the cellular cytoskeleton of WM239a melanoma cells through a process dependent on dishevelled (DSH), RhoB and Rab4 to promote cellular migration towards the source of the chemokine (Witze et al, 2008).