WNT5A and neoplasm: Downregulation of Wnt-5a has been associated with higher tumour grade (Kremenevskaja et al, 2005; Dejmek et al, 2005a; Liu et al, 2008) and was shown to be an independent factor indicating poor prognosis in a number of different tumour subtypes (Jonsson et al, 2002; Roman-Gomez et al, 2007).