TGFB1 and Telangiectasia: In this analysis, no association was observed between CVD and the inheritance of alleles of the XRCC1 (R399Q) SNP, previously linked to radiation-induced telangiectasiae, the fibrosis-associated TGFb1 (C-509T) gene promoter polymorphism (Giotopoulos et al, 2007) or the eNOS (E298D) SNP that confers a weak protective effect against radiotherapy-induced telangiectasiae (Giotopoulos et al, 2008).