Related to our study, an overexpression of BubR1 has been observed in several human cancers, including breast, gastric, bladder, kidney, and colorectal carcinomas (Myrie et al, 2000; Shichiri et al, 2002; Grabsch et al, 2003; Yamamoto et al, 2007; Pinto et al, 2008). This evidence concerns the gene BUB1B and cancer.