On the basis of the findings that IGF-I stimulation promotes phosphorylation of both 4E-BP1 and eIF4E, resulting in the inactive and active forms of these proteins, respectively, it was hypothesised that IGF-I stimulation of mesothelioma cells would result in an enhanced eIF4F function and increased translation. The gene discussed is EIF4EBP1; the disease is mesothelioma.