Finally, the level of eIF4G, the scaffolding component of the eIF4F complex necessary for the initiation of translation, was not affected by IGF-I stimulation and was mildly decreased upon LY294002 treatment in three of the five mesothelioma cell lines (H2052, H513, and H2596) and LP9 cells (Figure 1A). This evidence concerns the gene IGF1 and mesothelioma.