Dooley et al., reported on 507 women who had DL performed on at least one breast; 291 had a prior history of breast cancer, 10 had a history of lobular carcinoma in situ, 199 were high risk due to a Gail Model risk of ≥ 1.7, 4 were not at high risk of breast cancer, and only 3 were BRCA1/2 mutation carriers. The gene discussed is BRCA1; the disease is breast cancer.