ESR1 and ischemia: 1C and 1D; P < 0.05) and similar to ischemia-induced ERK activity. To determine whether Src might regulate CREB and ERα activity following ischemia, SU was employed. Levels of p-ERα and p-CREB in the 24 h reperfusion group showed obvious decrease in animals in which SU was administered (Figure. 1C and 1D; P < 0.05).