VHL and von Hippel-Lindau disease: In contrast to the other markers studied, α5 integrin levels seemed to correlate closely with VHL disease subtype in 786-O cells, with the lowest levels seen with wild-type VHL, slightly elevated levels seen with type 2A and 2C VHL mutants (2A: Y98H, Y112H; 2C: V84L), higher levels seen with a majority of the type 2B VHL mutants (R167Q, Y112N, Y98N) and still higher levels in the type 1 VHL mutants.