BUB3 and cancer: It is possible that ReoT3D infection may enhance the mitotic checkpoint activity in cancer cells with weakened mitotic checkpoint, for example, by upregulating the expression of mitotic checkpoint proteins (such as Mad1, Mad2, BubR1/Mad3, Bub1 and Bub3) [45], Cdk1 and/or cyclin B [45], or suppressing the anaphase-promoting complex/cyclosome activity [45].