Structural insight into the Vps10-D family has just recently been obtained by the structure determination of sortilin [19], but more structures will probably follow, since these proteins are now emerging as important players for central cellular functions in sorting and signaling and are firmly linked to several human disorders e.g. SorLA is implicated in Alzheimers disease, SorCS1 in type 2 diabetes and sortilin in age and trauma-induced neuronal cell death [30]. Here, SORT1 is linked to early-onset autosomal dominant Alzheimer disease.