AFF4 and breast cancer: Among the down-regulated genes were several transcription factors, including transcription factor 12 (TCF12) involved in control of immunoglobulin transcription [71], transcription factor 8 (TCF8), a negative regulator of cadherin [72], myeloblastosis oncogene (MYB), known to be involved in estrogen signalling in some breast cancer cells [73] and AF4/FMR2 family, member 4 (AF5Q31), which functions as a transcriptional regulator in testicular somatic cells, essential for male germ cell differentiation and survival [74].