This includes disordered proteins, mutations in which were associated with particular diseases, α-synuclein (one of the major players in the Parkinson's diseases pathogenesis), p53 (a key tumor-supressor protein), huntingtin (a protein involved in the Huntington's disease pathogenesis), BRCA1 (a breast and/or ovarian cancer-associated protein) and EWS-FLI1 fusion protein (a protein associated with the Ewing's sarcoma family of tumors). This evidence concerns the gene EWSR1 and Huntington disease.