Extraskeletal myxoid chondrosarcomas are not known to have a diagnostic immunohistochemical profile (18), but our two classic cases distinguished themselves from the other entities in being positive for CD117 and at least focally for bcl-2, while they were mainly negative for YKL-40 (one case exhibited a weak, granular reaction). The gene discussed is CHI3L1; the disease is chondrosarcoma.