Gene profiling has indicated neural/neuroendocrine differentiation (20, 21), and expression of YKL-40/CHI3L1 has been demonstrated by RT-PCR in 10 cases of extraskeletal myxoid chondrosarcomas, but without performing immunohistochemical staining for the protein (20), and the discrepancy may be caused by posttranslational modification. Here, CHI3L1 is linked to myxoid chondrosarcoma.