BCL2 and chondrosarcoma: However, in spite of these practical shortcomings, we found positivity in two of 10 grade I, six of 12 grade II and two of three grade III chondrosarcomas, in accordance with the findings of Bovée et al.(16) and Hameetman et al.(17), that up-regulation of bcl-2 is an early event in some (peripheral) tumors and a late occurrence in others (central ones).