D2-40, an antibody with several names (podoplanin, Aggrus, M2A and hT1α-2) is directed against a transmembrane glycoprotein, and its main use in diagnostic pathology is as a marker of lymphatic endothelium, germinal cell tumors and mesotheliomas, but it also reacts with myofibroblasts, chondrocytes and osteocytes (2, 14). Here, PDPN is linked to mesothelioma.