NR0B2 and gastric cancer: Recently, it was reported that SHP increases gene expression of cyclooxygenase-2 (COX-2) via the sequential transcriptional induction of a caudal-related homeobox gene (CDX1) in human gastric cancer cells.(46) With regard to its controversial regulatory propensity, these reports suggest that SHP may participate differently in various cellular functions depending on the cell type.