In ALS, ∼10% of cases are familial (FALS), usually autosomal dominant and mutations in the ubiquitously expressed enzyme superoxide dismutase 1 (SOD1), are causal in<25% of FALS [4], [5] and in ∼3% of sporadic ALS (SALS). Here, SOD1 is linked to amyotrophic lateral sclerosis.