TP53 and osteosarcoma: McHugh et al. compared the characteristics of radiation-induced craniofacial osteosarcoma with those of the corresponding primary tumors, and proposed that the poorer prognosis of radiation-induced osteosarcoma was related to the higher expression of adverse prognostic markers, such as p53, TP53 mutations, ezrin expression, and the higher proliferative activity [34].