To fully explore the role nNOS plays in these and other diseases, and to design inhibitors with therapeutic value, nNOS must be inhibited selectively without inhibition of the other isoforms, inducible NOS (iNOS) and endothelial NOS (eNOS); inhibition of eNOS could lead to side effects such as hypertension [5]. This evidence concerns the gene NOS3 and hypertensive disorder.