SLC6A3 and Parkinson disease: DAT gene deletion in the mouse results in hyperactivity (Gainetdinov 1997; Giros et al. 1996), and when tyrosine hydroxylase is also inhibited, these animals show physical behaviors (e.g., akinesia, rigidity, tremor) that phenotypically resemble the motor symptoms of PD (Sotnikova et al. 2006).