We concluded that in large numbers of sections we were able to prove that immunohistochemical detection p16INK4a expression can be used as a specific diagnostic marker of all degrees of cervical dysplasia and cervical cancer, and possibly as a surrogate marker for HPV infection, due to the relationship between p16INK4A and HPV E7 inactivated RB protein. This evidence concerns the gene CDKN2A and cervical carcinoma.