Sixteen different transcription factors (GATA-1 and -2, CDC5, Ebox, HOXA3, MSX-1, MZF1, PAX-2, -5 and -6, PBX-1, PPARalpha, PPARgamma, PU.1, SP1, YY1) are of particular interest with possible link to the DBA and TEC phenotypes (e.g. important for hematopoiesis, implicated in cancer development, strong general transcription factor). The gene discussed is SP1; the disease is cancer.