We found that by chemically stabilizing HIF-1α, REDD1 was upregulated and Akt/mTOR pathway was maintained inhibited in GBM derived cells exposed to high oxygen tension (Figure 3G), only p70S6K activation did occur and this may depend on effectors of p70S6K activation alternative to mTOR. This evidence concerns the gene DDIT4 and glioblastoma.