BMP2 and glioblastoma: While total Akt/mTOR signaling proteins resulted to be homogenously expressed both in GBM and normal cells after BMP2 treatment (Figure 4A and Figure S1A), we found that activation of Akt (Thr308) and also mTOR (Ser2448) occurred with time (Figure 4A,C,D), and, importantly, this activation was accelerated and improved under acute high oxygen exposure, remaining highly activated even after a long term BMP2 exposure (72 hr) (Figure 4B).