We have recently shown [3] that BMP2 in vitro treatment, known to promote glial differentiation in GBM derived cells [4], resulted to be less effective under hypoxia, suggesting that hypoxia and also HIF-1α may preserve GBM tumour cell stemness by de-sensitizing cells to pro-differentiating BMP2 stimulus [3]. This evidence concerns the gene HIF1A and glioblastoma.