Indeed, c-Myc expression has been demonstrated to be up-regulated in 70% of colon cancers [40] and its well documented effects include stimulation of cyclinD expression, inhibition of p21cip1 and p27kip1 expression and inactivation of Rb, leading to enhanced G1 to S-phase transition [39]. The gene discussed is MYC; the disease is malignant colon neoplasm.