ACTA1 and neoplasm: In addition, binary logistic regression showed that both high expression of α-SMA and intense and moderate Masson staining associate with tumour aggressiveness and were predictors of distant metachronous metastasis in univariate analysis (P = 0.05, OR 4.35, CI 0.99–19.12 for α-SMA; P = 0.024, OR 6.92, CI 1.29–37.05 for collagen deposition).