The average fluorescence ratio (c-Src/CK18) was 1.027 (SD, 0.049; range, 0.967 to 1.099) for LBC patients, and 1.086 (SD, 0.114; range, 0.916 to 1.234) for reduction-surgery patients. The gene discussed is KRT18; the disease is CDH1-related diffuse gastric and lobular breast cancer syndrome.