Liu et al.19 looked at 80 preoperative biopsies of patients histologically diagnosed with head and neck epidermoid carcinoma through immunohistochemistry for Ki-67 and correlated these findings to postoperative specimens, concluding that Ki-67 has a statistically significant predictive value to discern metastatic and non-metastatic carcinomas. Here, MKI67 is linked to metastatic carcinoma.