The generation of HIP1 and SH3GL3 knockout as well as transgenic animal models may help elucidate the normal function of huntingtin and may also help to understand the key steps in the neuropathogenesis of HD.Giorgini and coworkers [246], focused on elucidating the molecular mechanisms for the development of newer therapeutic strategies for HD using a yeast model of mutant huntingtin toxicity. This evidence concerns the gene SH3GL3 and Huntington disease.