To this end, we first screened a panel of human NSCLC cell lines and found that none of them expressed IL-12RB2 mRNA (Fig. 2A) due to methylation of a CpG island in exon 1 (not shown), as previously demonstrated for different malignant cells [1], [9], [20]. This evidence concerns the gene IL12RB2 and non-small cell lung carcinoma.