ERBB2 and breast neoplasm: To determine the relation between breast cancer cell line subtypes (luminal, basal-A, basal-B) and breast tumor subtypes (luminal-A, luminal-B, ERBB2, basal-like, and normal-like), we first classified cell lines according to tumor subtype using a nearest centroid approach applied to the set of “intrinsic genes” used originally to define the tumor subtypes [2], [3] (see Methods) (Fig. 2B).