Basal-B lines were characterized by markers associated with aggressive tumor features, including PLAT (plasminogen activator) [37] and TGFB1 [38] (Fig. 1C), as well as marker phenotypes associated with normal breast and breast cancer progenitor/stem cells (MUC−/CALLA+; CD44+/CD24−/low; and ITGB3(CD61)+) (Fig. 2C) [39]–[41]. Here, PLAT is linked to breast cancer.