We observed downregulation of the genes encoding kininogen (kng1), Apolipoprotein CI (Apoc1) and the neutrophil-associated leucine-rich alpha-2-glycoprotein 1 (Lrg1) amongst others, in aortas of mice resistant to aneurysm suggesting that they may be pathological genes. The gene discussed is KNG1; the disease is aneurysm.