Indeed, monoclonal antibodies isolated from individuals with type 1 diabetes mellitus have been employed successfully in identifying the antibody-binding sites on glutamic acid decarboxylase.(33) In future work, the isolation of anti-CaSR monoclonal antibodies from APS1 patients will allow a more complete and detailed analysis of the array of anti-CaSR antibodies and the epitopes they recognize. Here, CASR is linked to Autoimmune polyendocrinopathy type 1.