In contrary, Mabuchi et al. [19] found a significantly lower frequency of the APOE ε2 and ε4 alleles in Japanese patients with OAG, and Lam et al. [20] found lower frequency of the ε4 allele in patients with NTG, but not with high tension glaucoma in Chinese, indicating a protective effect of the ε4 allele against glaucoma. This evidence concerns the gene APOE and glaucoma.