APOE and early-onset autosomal dominant Alzheimer disease: Given the potential similarities between the cellular events leading to degeneration in both Alzheimer’s disease and glaucoma, the higher incidence of glaucoma in Alzheimer’s disease [15,16] and APOE ε4 allele as a risk factor for Alzheimer’s disease, APOE seems to be a pliable candidate for glaucoma susceptibility.