The clinical usefulness of cardiac natriuretic peptides (especially BNP and NT-proBNP) in the evaluation of patients with suspected heart failure, in prognostic stratification of patients with CHF, in detecting LV systolic or diastolic dysfunction and in the differential diagnosis of dyspnoea was confirmed (Cowie MR et al. 2003). The gene discussed is NPPB; the disease is congestive heart failure.