BRAF and neoplasm: However, as noted above, a clear relationship between BRAF mutations and aggressive tumour behaviour has not been demonstrated in all studies (Puxeddu et al. 2004; Kim et al. 2005; Trovisco et al. 2005; Fugazzola et al. 2006; Sapio et al. 2006; Abrosimov et al. 2007; Durante et al. 2007; Mitsiades et al. 2007), and the predictive value of BRAF mutations remains uncertain.